Reverse-Vine® is a proprietary extract from a blend of red wine, grape cluster stems, and grapevine. This age defying extract contains naturally occuring Trans-Resveratrol, OPC's, Polyphenols, and the newly discovered Trans-e-Viniferin only found in the grapevine.

Our key advantage is our exclusive extraction purification technology process to extract Trans-e-Viniferin and other important nutrients. This process produces highly concentrated molecules for optimum utilization to help reduce cell-oxidation.

Full Spectrum Anti-Aging Support

  • Superior SIRT-1 Activation*
  • 25% Increased SOD Activities*
  • Reduced Cell Oxidation*
  • Powerful Antioxidant*

Newly Discovered Molecule Beyond Resveratrol: TRANS-E-VINIFERIN

Trans-e-Viniferin is a natural compound produced by the grapevine as part of their defense system against disease and infection. Trans-e-Viniferin production is programmed to increase when the plant is exposed to stressful conditions therefore affecting the healing process by itself naturally.

25% Increased SOD Activity (Super Oxide Dismutase)

(SOD) is a critical enzyme that repairs cells, reduces free radical damage and acts as an anti-inflammatory in the body. Found in both the dermis and epidermis, SOD helps neutralize the free radicals that can lead to wrinkles and precancerous cell changes and is key to the production of healthy skin-building cells.

Reverse-Vine Clinicals Show:

  • 25% Increased SOD Activities vs Control
  • 7%  More Effective Than Resveratrol Alone*
  • 44% More Effective Than Control*
* After Oxidation Source Introduced

*After Oxidation Source Introduced To Subjects

A. Blank Control group
B. Reverse-vine®
C. Reversitall™
D. Resveratrol PCE-group
E. Model Control group

Superior SIRT-1 Longevity Gene Activation

Recent studies show that Reverse-Vine® "synergistic" key ingredients exhibited higher anti-oxidant activities and showed superior SIRT-1 (longevity gene) activation.

When the SIRT-1 gene is activated, it helps protect cells from inflammation and oxidative stress. This gene is believed to have a profound affect on lifespan, as studies have shown that animals with the SIRT-1 gene activated live, on average, as much as 40 percent longer than their counterparts.

Reverse-Vine® Prolongs Shelf Life of Fruit, Remarkable Water Retention, and Value Added Nutrients

Fruits and agriculture products are exposed to pathogen's attack and natural biological processes of deterioration during storage. Resveratrol (3, 5, 4'-trihydroxystilbene) has been described as one of the most important molecules for resistance to fungal diseases. Reverse-vine® ingredients work as a natural antibiotic to reduce microbal contamination. Its nutra-protection in fruit preserves during post-harvest to delivery to the market without the risk of spoilage and with added nutrient value. Reverse-vine® treatment inhibits mold and yeast development on grapes, tomatoes, mushrooms, and fruits, and preserves water content without effecting fruit firmness or nutrition. The use of Reverse-vine® as a natural pesticide and fertilizer are being investigated.


It is important to note that studies have shown that taking resveratrol alone may not be enough. According to Dr. Xi Zhao-Wilson, PhD, resveratrol is derived from natural plant extracts and usually in a mixture with many other molecules. In order to obtain the "optimal bioavailability and synergistic action" of resveratrol some of the other molecules that make up the stilbenes may be needed.

Reverse-Vine® offers a combination of all necessary molecules creating a natural environment wherein resveratrol can be more effective. Reverse-Vine® contains all-important nutrients especially Trans-e-Viniferin or (E)-e-Viniferin (a natural phenolic compound a resveratrol dimer) that, like trans-resveratrol or (E)-resveratrol [3, 4', 5-trihydroxytrans-stilbene], is present in grapevine. Unlike trans-resveratrol which in vitro, ex vivo, and in vivo experiments has shown a number of biological activities including anti-inflammatory, antioxidant, platelet anti-aggregatory and anti-carcinogenic properties.

(for reviews, see, e.g., Aggarwal et al., 2004;
Alarcon de la Lastra and Villegas, 2005;
Delmas et al., 2005;
Olas and Wachowicz, 2005;
Orallo, 2005; Orallo, 2006;
Ulrich et al., 2005)

This newly discovered molecule, e-Viniferin, has been reported to induce apoptosis of leukemia B-cells (Billard et al., 2002; Quiney et al., 2004), to exhibit hepatoprotective activity in cultured rat hepatocytes (Oshima et al.,1995), to inhibit human cytochrome P450 enzymes (Piver et al, 2003), and to have antioxidant capacity (Privat et al., 2002). Reverse-Vine® efficacy is backed by remarkable clinical research in vivo, vitro, and laboratory experiments.