Age effects the production of H.A. in the body, the average 70kg (154 lbs.) has an estimated 15 grams of H.A. in the body, one-third of which is turned over every day. When H.A. content production decreases with age a noticeable loss of viscoelasticity in tissue manifests itself in form of loose skin and wrinkles. Further, improper amounts of H.A. may inhibit the ability to move freely and painlessly and as a result one may experience arthritis, bone fractures, poor vision, and chronic pain. H.A. has been found to assist in regulation of cell turnover in the skin and serve as an anti-oxidant to free radicals.
Until the late 1970s, Hyaluronan was described as a ubiquitous carbohydrate polymer that is part of the extracellular matrix. For example, Hyaluronan is a major component of the synovial fluid and supplementing with H.A. was found to increase the viscosity of the synovial fluid, a lubricating component. Hyaluronan is an important component of articular cartilage where it is present as a coat around each cell (chondrocyte). It is responsible for the resilience of cartilage by binding water molecules to the cartilage.
Hyaluronan is also a major component of skin where it is involved in tissue repair. When skin is exposed to excessive UVB rays it becomes inflamed (sunburn) and the cells in the dermis stop producing as much Hyaluronan and increase the rate of its degradation. Hyaluronan degradation products then accumulate in the skin after UV exposure.
Scientific Research on oral delivery of H.A. reveals effective absorbency in joints. There is now substantial evidence that orally delivered Hyaluronan (H.A.) is effectively absorbed. A clinical conducted on humans demonstrated that after only a single oral intake, H.A. was absorbed and distributed to organs and joints.
Hyaluronan has been used for years in veterinary and human medicine to replace lost joint fluid but until recently was limited to injections or topical applications and no data on oral administration of H.A. was ever available. These latest findings validate the support of H.A. dietary supplementation and deliver anti-aging and joint health promises.